Eeyarestatin 24 impairs SecYEG‐dependent protein trafficking and inhibits growth of clinically relevant pathogens

Eeyarestatin 1 (ES1) is an inhibitor of endoplasmic reticulum (ER) associated protein degradation, Sec61‐dependent Ca(2+) homeostasis and protein translocation into the ER. Recently, evidence was presented showing that a smaller analog of ES1, ES24, targets the Sec61‐translocon, and captures it in a...

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Bibliographic Details
Published in:Mol Microbiol
Main Authors: Steenhuis, Maurice, Koningstein, Gregory M., Oswald, Julia, Pick, Tillman, O’Keefe, Sarah, Koch, Hans‐Georg, Cavalié, Adolfo, Whitehead, Roger C., Swanton, Eileithyia, High, Stephen, Luirink, Joen
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273874/
https://ncbi.nlm.nih.gov/pubmed/32798330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14589
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