Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC

Glioblastomas, which contain stem cell–like glioblastoma stem cells (GSCs), are universally lethal cancers. While neural stem cells (NSCs) are usually quiescent, single-cell studies suggest that proliferating glioblastoma cells reside in the GSC population. Interrogating in silico glioma databases f...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Zhang, Guoxin, Dong, Zhen, Prager, Briana C., Kim, Leo J.K., Wu, Qiulian, Gimple, Ryan C., Wang, Xiuxing, Bao, Shideng, Hamerlik, Petra, Rich, Jeremy N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483649/
https://ncbi.nlm.nih.gov/pubmed/30779712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126140
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