Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression

Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that drive these epigenetic changes remain unknown. Ly...

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Veröffentlicht in:Oncogenesis
Hauptverfasser: Zocchi, Loredana, Mehta, Aditi, Wu, Stephanie C., Wu, Jie, Gu, Yijun, Wang, Jingtian, Suh, Susie, Spitale, Robert C., Benavente, Claudia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028996/
https://ncbi.nlm.nih.gov/pubmed/32071286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-0210-7
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