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Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression

Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that drive these epigenetic changes remain unknown. Ly...

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Vydáno v:Oncogenesis
Hlavní autoři: Zocchi, Loredana, Mehta, Aditi, Wu, Stephanie C., Wu, Jie, Gu, Yijun, Wang, Jingtian, Suh, Susie, Spitale, Robert C., Benavente, Claudia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028996/
https://ncbi.nlm.nih.gov/pubmed/32071286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-0210-7
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