CXCR3 regulates CD4(+) T cell cardiotropism in pressure overload–induced cardiac dysfunction

Heart failure (HF) is associated in humans and mice with increased circulating levels of CXCL9 and CXCL10, chemokine ligands of the CXCR3 receptor, predominantly expressed on CD4(+) Th1 cells. Chemokine engagement of receptors is required for T cell integrin activation and recruitment to sites of in...

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Detalhes bibliográficos
Publicado no:JCI Insight
Principais autores: Ngwenyama, Njabulo, Salvador, Ane M., Velázquez, Francisco, Nevers, Tania, Levy, Alexander, Aronovitz, Mark, Luster, Andrew D., Huggins, Gordon S., Alcaide, Pilar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483643/
https://ncbi.nlm.nih.gov/pubmed/30779709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125527
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