Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation

Heart Failure (HF) is associated with increased circulating levels of aldosterone and systemic inflammation. Mineralocorticoid receptor (MR) antagonists block aldosterone action and decrease mortality in patients with congestive HF. However, the molecular mechanisms underlying the therapeutic benefi...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Salvador, Ane M., Moss, M. Elizabeth, Aronovitz, Mark, Mueller, Kathleen B., Blanton, Robert M., Jaffe, Iris Z., Alcaide, Pilar
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492203/
https://ncbi.nlm.nih.gov/pubmed/28637706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13313
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