CXCR3 regulates CD4(+) T cell cardiotropism in pressure overload–induced cardiac dysfunction

Heart failure (HF) is associated in humans and mice with increased circulating levels of CXCL9 and CXCL10, chemokine ligands of the CXCR3 receptor, predominantly expressed on CD4(+) Th1 cells. Chemokine engagement of receptors is required for T cell integrin activation and recruitment to sites of in...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Ngwenyama, Njabulo, Salvador, Ane M., Velázquez, Francisco, Nevers, Tania, Levy, Alexander, Aronovitz, Mark, Luster, Andrew D., Huggins, Gordon S., Alcaide, Pilar
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483643/
https://ncbi.nlm.nih.gov/pubmed/30779709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125527
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