Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation

Heart Failure (HF) is associated with increased circulating levels of aldosterone and systemic inflammation. Mineralocorticoid receptor (MR) antagonists block aldosterone action and decrease mortality in patients with congestive HF. However, the molecular mechanisms underlying the therapeutic benefi...

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Bibliografiske detaljer
Udgivet i:Physiol Rep
Main Authors: Salvador, Ane M., Moss, M. Elizabeth, Aronovitz, Mark, Mueller, Kathleen B., Blanton, Robert M., Jaffe, Iris Z., Alcaide, Pilar
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492203/
https://ncbi.nlm.nih.gov/pubmed/28637706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13313
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