Small-hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevent diaphragm weakness in rats with heart failure and reduced ejection fraction

Heart failure with reduced ejection fraction (HFREF) increases neutral sphingomyelinase (NSMase) activity and mitochondrial reactive oxygen species (ROS) emission and causes diaphragm weakness. We tested whether a systemic pharmacological NSMase inhibitor or short-hairpin RNA (shRNA) targeting NSMas...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Lung Cell Mol Physiol
Prif Awduron: Coblentz, Philip D., Ahn, Bumsoo, Hayward, Linda F., Yoo, Jeung-Ki, Christou, Demetra D., Ferreira, Leonardo F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483012/
https://ncbi.nlm.nih.gov/pubmed/30702345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00516.2018
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