Small-hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevent diaphragm weakness in rats with heart failure and reduced ejection fraction

Heart failure with reduced ejection fraction (HFREF) increases neutral sphingomyelinase (NSMase) activity and mitochondrial reactive oxygen species (ROS) emission and causes diaphragm weakness. We tested whether a systemic pharmacological NSMase inhibitor or short-hairpin RNA (shRNA) targeting NSMas...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Lung Cell Mol Physiol
Asıl Yazarlar: Coblentz, Philip D., Ahn, Bumsoo, Hayward, Linda F., Yoo, Jeung-Ki, Christou, Demetra D., Ferreira, Leonardo F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483012/
https://ncbi.nlm.nih.gov/pubmed/30702345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00516.2018
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