Small-hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevent diaphragm weakness in rats with heart failure and reduced ejection fraction

Heart failure with reduced ejection fraction (HFREF) increases neutral sphingomyelinase (NSMase) activity and mitochondrial reactive oxygen species (ROS) emission and causes diaphragm weakness. We tested whether a systemic pharmacological NSMase inhibitor or short-hairpin RNA (shRNA) targeting NSMas...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Coblentz, Philip D., Ahn, Bumsoo, Hayward, Linda F., Yoo, Jeung-Ki, Christou, Demetra D., Ferreira, Leonardo F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483012/
https://ncbi.nlm.nih.gov/pubmed/30702345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00516.2018
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