Myeloid folliculin balances mTOR activation to maintain innate immunity homeostasis

The mTOR pathway is central to most cells. How mTOR is activated in macrophages and how it modulates macrophage physiology remain poorly understood. The tumor suppressor folliculin (FLCN) is a GAP for RagC/D, a regulator of mTOR. We show here that LPS potently suppresses FLCN in macrophages, allowin...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Li, Jia, Wada, Shogo, Weaver, Lehn K., Biswas, Chhanda, Behrens, Edward M., Arany, Zoltan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483010/
https://ncbi.nlm.nih.gov/pubmed/30843872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126939
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