Myeloid folliculin balances mTOR activation to maintain innate immunity homeostasis

The mTOR pathway is central to most cells. How mTOR is activated in macrophages and how it modulates macrophage physiology remain poorly understood. The tumor suppressor folliculin (FLCN) is a GAP for RagC/D, a regulator of mTOR. We show here that LPS potently suppresses FLCN in macrophages, allowin...

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Vydáno v:JCI Insight
Hlavní autoři: Li, Jia, Wada, Shogo, Weaver, Lehn K., Biswas, Chhanda, Behrens, Edward M., Arany, Zoltan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483010/
https://ncbi.nlm.nih.gov/pubmed/30843872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126939
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