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Myeloid folliculin balances mTOR activation to maintain innate immunity homeostasis
The mTOR pathway is central to most cells. How mTOR is activated in macrophages and how it modulates macrophage physiology remain poorly understood. The tumor suppressor folliculin (FLCN) is a GAP for RagC/D, a regulator of mTOR. We show here that LPS potently suppresses FLCN in macrophages, allowin...
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| Pubblicato in: | JCI Insight |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6483010/ https://ncbi.nlm.nih.gov/pubmed/30843872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126939 |
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