PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unremitting extracellular matrix deposition, leading to a distortion of pulmonary architecture and impaired gas exchange. Fibroblasts from IPF patients acquire an invasive phenotype that is essential for progressive fibrosis. Here, we...

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Опубликовано в: :JCI Insight
Главные авторы: Geng, Yan, Liu, Xue, Liang, Jiurong, Habiel, David M., Kulur, Vrishika, Coelho, Ana Lucia, Deng, Nan, Xie, Ting, Wang, Yizhou, Liu, Ningshan, Huang, Guanling, Kurkciyan, Adrianne, Liu, Zhenqiu, Tang, Jie, Hogaboam, Cory M., Jiang, Dianhua, Noble, Paul W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482997/
https://ncbi.nlm.nih.gov/pubmed/30763282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125326
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