PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unremitting extracellular matrix deposition, leading to a distortion of pulmonary architecture and impaired gas exchange. Fibroblasts from IPF patients acquire an invasive phenotype that is essential for progressive fibrosis. Here, we...

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Udgivet i:JCI Insight
Main Authors: Geng, Yan, Liu, Xue, Liang, Jiurong, Habiel, David M., Kulur, Vrishika, Coelho, Ana Lucia, Deng, Nan, Xie, Ting, Wang, Yizhou, Liu, Ningshan, Huang, Guanling, Kurkciyan, Adrianne, Liu, Zhenqiu, Tang, Jie, Hogaboam, Cory M., Jiang, Dianhua, Noble, Paul W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482997/
https://ncbi.nlm.nih.gov/pubmed/30763282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125326
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