Mesenchymal growth hormone receptor deficiency leads to failure of alveolar progenitor cell function and severe pulmonary fibrosis

Recent studies have identified impaired type 2 alveolar epithelial cell (ATII) renewal in idiopathic pulmonary fibrosis (IPF) human organoids and severe fibrosis when ATII is defective in mice. ATIIs function as progenitor cells and require supportive signals from the surrounding mesenchymal cells....

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Xie, Ting, Kulur, Vrishika, Liu, Ningshan, Deng, Nan, Wang, Yizhou, Rowan, Simon Coyle, Yao, Changfu, Huang, Guanling, Liu, Xue, Taghavifar, Forough, Liang, Jiurong, Hogaboam, Cory, Stripp, Barry, Chen, Peter, Jiang, Dianhua, Noble, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8189579/
https://ncbi.nlm.nih.gov/pubmed/34108218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg6005
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