Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial

BACKGROUND: Convenient, safe, and effective treatments for visceral leishmaniasis in Eastern African children are lacking. Miltefosine, the only oral treatment, failed to achieve adequate efficacy, particularly in children, in whom linear dosing (2.5 mg/kg/day for 28 days) resulted in a 59% cure rat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Infect Dis
Egile Nagusiak: Mbui, Jane, Olobo, Joseph, Omollo, Raymond, Solomos, Alexandra, Kip, Anke E, Kirigi, George, Sagaki, Patrick, Kimutai, Robert, Were, Lilian, Omollo, Truphosa, Egondi, Thaddaeus W, Wasunna, Monique, Alvar, Jorge, Dorlo, Thomas P C, Alves, Fabiana
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2019
Gaiak:
Articles and Commentaries
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481997/
https://ncbi.nlm.nih.gov/pubmed/30188978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciy747
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