Characterizing the non-linear pharmacokinetics of miltefosine in paediatric visceral leishmaniasis patients from Eastern Africa

BACKGROUND: Conventional miltefosine dosing (2.5 mg/kg/day) for treatment of visceral leishmaniasis (VL) is less effective in children than in adults. A higher allometric dose (median 3.2 mg/kg/day) was therefore investigated in paediatric VL patients in Eastern Africa. Results of this trial showed...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Palić, Semra, Kip, Anke E, Beijnen, Jos H, Mbui, Jane, Musa, Ahmed, Solomos, Alexandra, Wasunna, Monique, Olobo, Joseph, Alves, Fabiana, Dorlo, Thomas P C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566410/
https://ncbi.nlm.nih.gov/pubmed/32780098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa314
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