Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study

BACKGROUND: Low efficacy of miltefosine in the treatment of visceral leishmaniasis was recently observed in Eastern Africa. OBJECTIVES: To describe the pharmacokinetics and establish a pharmacokinetic/pharmacodynamic relationship for miltefosine in Eastern African patients with visceral leishmaniasi...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Dorlo, Thomas P C, Kip, Anke E, Younis, Brima M, Ellis, Sally J, Alves, Fabiana, Beijnen, Jos. H, Njenga, Simon, Kirigi, George, Hailu, Asrat, Olobo, Joseph, Musa, Ahmed M, Balasegaram, Manica, Wasunna, Monique, Karlsson, Mats O, Khalil, Eltahir A G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890687/
https://ncbi.nlm.nih.gov/pubmed/28961737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx283
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