Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial

BACKGROUND: Convenient, safe, and effective treatments for visceral leishmaniasis in Eastern African children are lacking. Miltefosine, the only oral treatment, failed to achieve adequate efficacy, particularly in children, in whom linear dosing (2.5 mg/kg/day for 28 days) resulted in a 59% cure rat...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: Mbui, Jane, Olobo, Joseph, Omollo, Raymond, Solomos, Alexandra, Kip, Anke E, Kirigi, George, Sagaki, Patrick, Kimutai, Robert, Were, Lilian, Omollo, Truphosa, Egondi, Thaddaeus W, Wasunna, Monique, Alvar, Jorge, Dorlo, Thomas P C, Alves, Fabiana
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Articles and Commentaries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481997/
https://ncbi.nlm.nih.gov/pubmed/30188978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciy747
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