Temperature-Responsive Competitive Inhibition of CRISPR-Cas9

CRISPR-Cas immune systems utilize RNA-guided nucleases to protect bacteria from bacteriophage infection. Bacteriophages have in turn evolved inhibitory “anti-CRISPR” (Acr) proteins, including six inhibitors (AcrIIA1–AcrIIA6) that can block DNA cutting and genome editing by type II-A CRISPR-Cas9 enzy...

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Publicat a:Mol Cell
Autors principals: Jiang, Fuguo, Liu, Jun-Jie, Osuna, Beatriz A., Xu, Michael, Berry, Joel D., Rauch, Benjamin J., Nogales, Eva, Bondy-Denomy, Joseph, Doudna, Jennifer A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6480404/
https://ncbi.nlm.nih.gov/pubmed/30595438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.11.016
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