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In Vitro and In Silico Evaluation of Bikaverin as a Potent Inhibitor of Human Protein Kinase CK2

Protein kinase CK2 is an emerging target for therapeutic intervention in human diseases, particularly in cancer. Inhibitors of this enzyme are currently in clinical trials, indicating the druggability of human CK2. By virtual screening of the ZINC database, we found that the natural compound bikaver...

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Bibliografske podrobnosti
izdano v:Molecules
Main Authors: Haidar, Samer, Aichele, Dagmar, Birus, Robin, Hielscher, Janine, Laitinen, Tuomo, Poso, Antti, Jose, Joachim
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479664/
https://ncbi.nlm.nih.gov/pubmed/30965682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24071380
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