HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type 1 diabetes using both bulk-sorted and single β-cells. Co...

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Détails bibliographiques
Publié dans:Diabetes
Auteurs principaux: Russell, Mark A., Redick, Sambra D., Blodgett, David M., Richardson, Sarah J., Leete, Pia, Krogvold, Lars, Dahl-Jørgensen, Knut, Bottino, Rita, Brissova, Marcela, Spaeth, Jason M., Babon, Jenny Aurielle B., Haliyur, Rachana, Powers, Alvin C., Yang, Chaoxing, Kent, Sally C., Derr, Alan G., Kucukural, Alper, Garber, Manuel G., Morgan, Noel G., Harlan, David M.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2019
Sujets:
Islet Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477908/
https://ncbi.nlm.nih.gov/pubmed/30833470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0686
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