HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type 1 diabetes using both bulk-sorted and single β-cells. Co...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Russell, Mark A., Redick, Sambra D., Blodgett, David M., Richardson, Sarah J., Leete, Pia, Krogvold, Lars, Dahl-Jørgensen, Knut, Bottino, Rita, Brissova, Marcela, Spaeth, Jason M., Babon, Jenny Aurielle B., Haliyur, Rachana, Powers, Alvin C., Yang, Chaoxing, Kent, Sally C., Derr, Alan G., Kucukural, Alper, Garber, Manuel G., Morgan, Noel G., Harlan, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2019
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477908/
https://ncbi.nlm.nih.gov/pubmed/30833470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0686
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