HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type 1 diabetes using both bulk-sorted and single β-cells. Co...

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Bibliografische gegevens
Gepubliceerd in:Diabetes
Hoofdauteurs: Russell, Mark A., Redick, Sambra D., Blodgett, David M., Richardson, Sarah J., Leete, Pia, Krogvold, Lars, Dahl-Jørgensen, Knut, Bottino, Rita, Brissova, Marcela, Spaeth, Jason M., Babon, Jenny Aurielle B., Haliyur, Rachana, Powers, Alvin C., Yang, Chaoxing, Kent, Sally C., Derr, Alan G., Kucukural, Alper, Garber, Manuel G., Morgan, Noel G., Harlan, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Diabetes Association 2019
Onderwerpen:
Islet Studies
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477908/
https://ncbi.nlm.nih.gov/pubmed/30833470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0686
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