HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type 1 diabetes using both bulk-sorted and single β-cells. Co...

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Опубликовано в: :Diabetes
Главные авторы: Russell, Mark A., Redick, Sambra D., Blodgett, David M., Richardson, Sarah J., Leete, Pia, Krogvold, Lars, Dahl-Jørgensen, Knut, Bottino, Rita, Brissova, Marcela, Spaeth, Jason M., Babon, Jenny Aurielle B., Haliyur, Rachana, Powers, Alvin C., Yang, Chaoxing, Kent, Sally C., Derr, Alan G., Kucukural, Alper, Garber, Manuel G., Morgan, Noel G., Harlan, David M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2019
Предметы:
Islet Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477908/
https://ncbi.nlm.nih.gov/pubmed/30833470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0686
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