Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks

Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-e...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Haliyur, Rachana, Tong, Xin, Sanyoura, May, Shrestha, Shristi, Lindner, Jill, Saunders, Diane C., Aramandla, Radhika, Poffenberger, Greg, Redick, Sambra D., Bottino, Rita, Prasad, Nripesh, Levy, Shawn E., Blind, Raymond D., Harlan, David M., Philipson, Louis H., Stein, Roland W., Brissova, Marcela, Powers, Alvin C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2018
Gaiak:
Concise Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307934/
https://ncbi.nlm.nih.gov/pubmed/30507613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121994
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