Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks

Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-e...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Haliyur, Rachana, Tong, Xin, Sanyoura, May, Shrestha, Shristi, Lindner, Jill, Saunders, Diane C., Aramandla, Radhika, Poffenberger, Greg, Redick, Sambra D., Bottino, Rita, Prasad, Nripesh, Levy, Shawn E., Blind, Raymond D., Harlan, David M., Philipson, Louis H., Stein, Roland W., Brissova, Marcela, Powers, Alvin C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307934/
https://ncbi.nlm.nih.gov/pubmed/30507613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121994
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