Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks

Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-e...

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Vydáno v:J Clin Invest
Hlavní autoři: Haliyur, Rachana, Tong, Xin, Sanyoura, May, Shrestha, Shristi, Lindner, Jill, Saunders, Diane C., Aramandla, Radhika, Poffenberger, Greg, Redick, Sambra D., Bottino, Rita, Prasad, Nripesh, Levy, Shawn E., Blind, Raymond D., Harlan, David M., Philipson, Louis H., Stein, Roland W., Brissova, Marcela, Powers, Alvin C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Concise Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307934/
https://ncbi.nlm.nih.gov/pubmed/30507613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121994
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