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Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks
Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-e...
Gorde:
| Argitaratua izan da: | J Clin Invest |
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| Egile Nagusiak: | , , , , , , , , , , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Clinical Investigation
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6307934/ https://ncbi.nlm.nih.gov/pubmed/30507613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121994 |
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