Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells

Pancreatic islets secrete insulin from β cells and glucagon from α cells, and dysregulated secretion of these hormones is a central component of diabetes. Thus, an improved understanding of the pathways governing coordinated β and α cell hormone secretion will provide insight into islet dysfunction...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Walker, John T., Haliyur, Rachana, Nelson, Heather A., Ishahak, Matthew, Poffenberger, Gregory, Aramandla, Radhika, Reihsmann, Conrad, Luchsinger, Joseph R., Saunders, Diane C., Wang, Peng, Garcia-Ocaña, Adolfo, Bottino, Rita, Agarwal, Ashutosh, Powers, Alvin C., Brissova, Marcela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259531/
https://ncbi.nlm.nih.gov/pubmed/32352931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137017
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