Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks

Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-e...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Haliyur, Rachana, Tong, Xin, Sanyoura, May, Shrestha, Shristi, Lindner, Jill, Saunders, Diane C., Aramandla, Radhika, Poffenberger, Greg, Redick, Sambra D., Bottino, Rita, Prasad, Nripesh, Levy, Shawn E., Blind, Raymond D., Harlan, David M., Philipson, Louis H., Stein, Roland W., Brissova, Marcela, Powers, Alvin C.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Concise Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307934/
https://ncbi.nlm.nih.gov/pubmed/30507613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121994
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