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MEDU-39. HIGHLY RECURRENT U1 SMALL NUCLEAR RNA HOTSPOT MUTATIONS DRIVE ALTERNATIVE SPLICING IN SONIC HEDGEHOG MEDULLOBLASTOMA

Recurrent somatic single nucleotide variants (SNVs) in cancer are largely confined to protein-coding genes, and are rare in pediatric cancers. Similar to many pediatric cancers, medulloblastomas harbor few recurrent somatic SNVs except for TERT promoter mutations. To investigate non-coding mutations...

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Опубликовано в: :Neuro Oncol
Главные авторы: Kumar, Sachin, Suzuki, Hiromichi, Shuai, Shimin, Stein, Lincoln, Taylor, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477429/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.197
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