TMOD-10. REPLICATION REPAIR DEFICIENT MOUSE MODELS PROVIDE INSIGHT ON HYPERMUTANT BRAIN TUMOURS AND COMBINATIONAL IMMUNOTHERAPY

Replication repair deficiency (RRD) is the leading cause of hypermutant brain tumours in children. RRD is caused by defects in one of four mismatch repair (MMR) genes—PMS2, MSH6, MLH1, and MSH2—as well as mutations in the exonuclease “proofreading” domains of either DNA polymerase ε (POLE) or δ (POL...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Galati, Melissa, Bridge, Taylor, Sudhaman, Sumedha, Elshaer, Dana, Ercan, Ayse, Joksimovic, Lazar, Gams, Miki, Hodel, Karl, Lipman, Tatiana, Siddiqui, Iram, de Borja, Richard, Forster, Victoria, Martin, Alberto, Bouffet, Eric, Shlien, Adam, Guidos, Cynthia, Pursell, Zachary, Hawkins, Cynthia, Tabori, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Pediatric Brain Tumor Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477416/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.248
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