TMOD-10. REPLICATION REPAIR DEFICIENT MOUSE MODELS PROVIDE INSIGHT ON HYPERMUTANT BRAIN TUMOURS AND COMBINATIONAL IMMUNOTHERAPY

Replication repair deficiency (RRD) is the leading cause of hypermutant brain tumours in children. RRD is caused by defects in one of four mismatch repair (MMR) genes—PMS2, MSH6, MLH1, and MSH2—as well as mutations in the exonuclease “proofreading” domains of either DNA polymerase ε (POLE) or δ (POL...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Galati, Melissa, Bridge, Taylor, Sudhaman, Sumedha, Elshaer, Dana, Ercan, Ayse, Joksimovic, Lazar, Gams, Miki, Hodel, Karl, Lipman, Tatiana, Siddiqui, Iram, de Borja, Richard, Forster, Victoria, Martin, Alberto, Bouffet, Eric, Shlien, Adam, Guidos, Cynthia, Pursell, Zachary, Hawkins, Cynthia, Tabori, Uri
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Pediatric Brain Tumor Models
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477416/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.248
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