THER-34. MEK BLOCKADE SYNERGISTICALLY INCREASES THE ANTI-TUMOR EFFECTS OF mTOR INHIBITION IN GLIOMAS

Abnormal signaling of the RAS/RAF and mTOR pathways predominates in pediatric low-grade gliomas (PLGGs). MLN0128 is a second-generation pan-mTOR inhibitor (TORC1/2). Rapalink-1, a third-generation bivalent mTOR inhibitor that combines rapamycin with MLN0128 by an inert chemical linker, shows potent...

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Publicado en:Neuro Oncol
Autores principales: Zhang, Jie, Liu, Kevin, Dik, Rogier, Yang, Xiaodong, Waanders, Angela, Resnick, Adam, Wright, Karen, Weiss, William, Haas-Kogan, Daphne, Mueller, Sabine
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477411/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.238
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