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THER-34. MEK BLOCKADE SYNERGISTICALLY INCREASES THE ANTI-TUMOR EFFECTS OF mTOR INHIBITION IN GLIOMAS
Abnormal signaling of the RAS/RAF and mTOR pathways predominates in pediatric low-grade gliomas (PLGGs). MLN0128 is a second-generation pan-mTOR inhibitor (TORC1/2). Rapalink-1, a third-generation bivalent mTOR inhibitor that combines rapamycin with MLN0128 by an inert chemical linker, shows potent...
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| 出版年: | Neuro Oncol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477411/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.238 |
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