TRTH-31. EFFECTS OF TORC1/2 INHIBITOR MLN0128 ALONE AND IN COMBINATION WITH MEK INHIBITION IN BRAF MUTATED GLIOMA CELLS

INTRODUCTION: MLN0128, a second-generation ATP-competitive pan-mTOR kinase inhibitor, acts on both mTORC1 and mTORC2. We investigated the effects of MLN0128 monotherapy and in combination with MEK and BRAFV600E inhibition in models of pediatric low-grade glioma (PLGG). METHODS: We used human glioma...

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Publié dans:Neuro Oncol
Auteurs principaux: Mueller, Sabine, Dirk, Rogier, Yang, Xiaodong, DuBois, Steve, Waanders, Angela, Resnick, Adam, Weiss, William, Haas-Kogan, Daphne
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475214/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.241
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