DIPG-07. EPIGENOME SCREENING IDENTIFIES TRANSCRIPTIONAL ELONGATION AS THERAPEUTIC VULNERABILITY IN H3K27M-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA

Mutations in the histone 3 (H3) gene (H3K27M) are the eponymous driver in diffuse intrinsic pontine gliomas (DIPGs), aggressive pediatric brain tumors for which no curative therapy currently exists. In order to identify specific epigenetic dependencies which arise as a consequence of the H3K27M muta...

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Publicado en:Neuro Oncol
Main Authors: Dahl, Nathan, Balakrishnan, Ilango, Wang, Dong, Danis, Etienne, Madhavan, Krishna, Fosmire, Susan, Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Diffuse Intrinsic Pontine Glioma (DIPG)
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477333/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.028
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