DIPG-07. EPIGENOME SCREENING IDENTIFIES TRANSCRIPTIONAL ELONGATION AS THERAPEUTIC VULNERABILITY IN H3K27M-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA

Mutations in the histone 3 (H3) gene (H3K27M) are the eponymous driver in diffuse intrinsic pontine gliomas (DIPGs), aggressive pediatric brain tumors for which no curative therapy currently exists. In order to identify specific epigenetic dependencies which arise as a consequence of the H3K27M muta...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Dahl, Nathan, Balakrishnan, Ilango, Wang, Dong, Danis, Etienne, Madhavan, Krishna, Fosmire, Susan, Venkataraman, Sujatha, Vibhakar, Rajeev
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Diffuse Intrinsic Pontine Glioma (DIPG)
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477333/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.028
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