PDTM-41. SUPER ELONGATION COMPLEX-MEDIATED TRANSCRIPTIONAL DEPENDENCY IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMAS

Mutations in the histone 3 (H3) gene (H3K27M) are the eponymous driver in diffuse midline gliomas (DMGs), aggressive pediatric brain tumors for which no curative therapy currently exists. Emerging understanding of H3K27M biology suggests that secondary factors are required to promote oncogenesis. In...

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Pubblicato in:Neuro Oncol
Autori principali: Dahl, Nathan, Venkataraman, Sujatha, Balakrishnan, Ilango, Madhavan, Krishna, Fosmire, Susan, Wang, Dong, Vibhakar, Rajeev
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217459/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.880
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