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PDTM-41. SUPER ELONGATION COMPLEX-MEDIATED TRANSCRIPTIONAL DEPENDENCY IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMAS

Mutations in the histone 3 (H3) gene (H3K27M) are the eponymous driver in diffuse midline gliomas (DMGs), aggressive pediatric brain tumors for which no curative therapy currently exists. Emerging understanding of H3K27M biology suggests that secondary factors are required to promote oncogenesis. In...

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Publicado en:Neuro Oncol
Main Authors: Dahl, Nathan, Venkataraman, Sujatha, Balakrishnan, Ilango, Madhavan, Krishna, Fosmire, Susan, Wang, Dong, Vibhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217459/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.880
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