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DIPG-10. THE ONCOGENIC ROLE OF THE SUPER ELONGATION COMPLEX IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMAS

Mutations in the histone 3 (H3) gene (H3K27M) are the eponymous driver in diffuse midline gliomas (DMGs). Emerging understanding of H3K27M biology suggests that secondary cooperating factors are required to promote oncogenesis. We have identified AFF4, a component of the super elongation complex (SE...

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書誌詳細
出版年:Neuro Oncol
主要な著者: Dahl, Nathan A, Venkataraman, Sujatha, Balakrishnan, Ilango, Madhavan, Krishna, Fosmire, Susan, Vibhakar, Rajeev
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012884/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.103
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