DIPG-13. A NOVEL MOUSE MODEL REVEALS UNEXPECTED MECHANISMS OF ACTION OF ACVR1 MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse Intrinsic Pontine Gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Most DIPGs are driven by mutations in histone H3-encoding genes, and a subset of these tumors also carry gain-of-function mutations in ACVR1, which encodes a BMP type...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Fortin, Jerome, Tian, Ruxiao, Zarrabi, Ida, Hill, Graham, Williams, Eleanor, Sanchez-Duffhues, Gonzalo, Thorikay, Midory, Ramachandran, Parameswaran, Siddaway, Robert, Wong, Jong, Haight, Jillian, You-Ten, Annick, Snow, Bryan, Wakeham, Andrew, Schramek, Daniel, Bullock, Alex, Dijke, Peter ten, Hawkins, Cynthia, Mak, Tak
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Diffuse Intrinsic Pontine Glioma (DIPG)
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477332/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.034
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