DIPG-13. A NOVEL MOUSE MODEL REVEALS UNEXPECTED MECHANISMS OF ACTION OF ACVR1 MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse Intrinsic Pontine Gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Most DIPGs are driven by mutations in histone H3-encoding genes, and a subset of these tumors also carry gain-of-function mutations in ACVR1, which encodes a BMP type...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Fortin, Jerome, Tian, Ruxiao, Zarrabi, Ida, Hill, Graham, Williams, Eleanor, Sanchez-Duffhues, Gonzalo, Thorikay, Midory, Ramachandran, Parameswaran, Siddaway, Robert, Wong, Jong, Haight, Jillian, You-Ten, Annick, Snow, Bryan, Wakeham, Andrew, Schramek, Daniel, Bullock, Alex, Dijke, Peter ten, Hawkins, Cynthia, Mak, Tak
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Diffuse Intrinsic Pontine Glioma (DIPG)
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477332/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.034
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