DIPG-09. CRISPR GENE EDITING OF ENDOGENOUS MUTANT FORMS OF H3.3 DEFINES ONCOHISTONE MECHANISMS AND NEW THERAPEUTIC APPROACHES

Pediatric high-grade gliomas often contain mutations in the H3F3A gene encoding the histone variant H3.3 and more rarely in canonical histone H3 family genes, a feature distinguishing them from adult gliomas. To define specific functionally significant changes in epigenomic states driven by mutant H...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Chen, Michael, Bush, Kelly, Klein, Rachel, Cervantes, Vanessa, Lewis, Nichole, Naqvi, Aasim, Carcaboso, Angel Montero, Knoepfler, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Diffuse Intrinsic Pontine Glioma (DIPG)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477327/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.030
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