Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling

Histone H3.3 mutations are a hallmark of pediatric gliomas, but their core oncogenic mechanisms are not well-defined. To identify major effectors, we used CRISPR-Cas9 to introduce H3.3K27M and G34R mutations into previously H3.3-wildtype brain cells, while in parallel reverting the mutations in glio...

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Gepubliceerd in:Commun Biol
Hoofdauteurs: Chen, Kuang-Yui, Bush, Kelly, Klein, Rachel Herndon, Cervantes, Vanessa, Lewis, Nichole, Naqvi, Aasim, Carcaboso, Angel M., Lechpammer, Mirna, Knoepfler, Paul S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347881/
https://ncbi.nlm.nih.gov/pubmed/32647372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1076-0
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