PDTM-26. NOVEL SHARED AND DISTINCT EPIGENOMIC MECHANISMS OF G34R AND K27M MUTATIONS IN CHILDHOOD GLIOMA

Alterations in histone H3.3 are common driver mutations in high-grade pediatric gliomas, but the central oncogenic mechanisms remain an open question. To identify important mutant H3.3 effectors, we used CRISPR-Cas9 to precisely introduce H3.3 K27M and G34R mutations into previously H3.3-wildtype hu...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Chen, Michael, Bush, Kelly, Lewis, Nichole, Cervantes, Vanessa, Knoepfler, Paul
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Pediatric Tumors
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847561/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.802
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