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DIPG-23. EFFICACY OF THE SOLUBLE PANOBINOSTAT (MTX110) IN PRECLINICAL DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) MODELS
INTRODUCTION: Large drug screening and preclinical studies identified the pan-histone deacetylate inhibitor panobinostat as a promising treatment for DIPG. However, blood brain barrier functional integrity in DIPG limits drug penetration and remains a key cause of resistance to therapies. Therefore,...
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| Publicado en: | Neuro Oncol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477314/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.044 |
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