MEDU-07. THE DEVELOPMENTAL STAGE OF THE MEDULLOBLASTOMA CELL-OF-ORIGIN IS MAINTAINED IN CANCER AND RESTRICTS HEDGEHOG PATHWAY USAGE AND DRUG SENSITIVITY

Sonic Hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) population that depends on Hedgehog signaling for its expansion. While SHH tumors are characterized by an overall deregulation of this pathway, they also exhibit aberrations that are specific for pat...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Smit, Marlinde, Armandari, Inna, Bockaj, Irena, Martini, Tosca, Zomerman, Walderik, Siragna, Zillah, Meeuwsen-de Boer, Tiny, Scherpen, Frank, Schoots, Mirthe, Ritsema, Martha, den Dunnen, Wilfred, Hoving, Eelco, Paridaen, Judith, de Haan, Gerald, Guryev, Victor, Bruggeman, Sophia
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Medulloblastoma
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477304/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.167
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