MEDU-07. THE DEVELOPMENTAL STAGE OF THE MEDULLOBLASTOMA CELL-OF-ORIGIN IS MAINTAINED IN CANCER AND RESTRICTS HEDGEHOG PATHWAY USAGE AND DRUG SENSITIVITY

Sonic Hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) population that depends on Hedgehog signaling for its expansion. While SHH tumors are characterized by an overall deregulation of this pathway, they also exhibit aberrations that are specific for pat...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Smit, Marlinde, Armandari, Inna, Bockaj, Irena, Martini, Tosca, Zomerman, Walderik, Siragna, Zillah, Meeuwsen-de Boer, Tiny, Scherpen, Frank, Schoots, Mirthe, Ritsema, Martha, den Dunnen, Wilfred, Hoving, Eelco, Paridaen, Judith, de Haan, Gerald, Guryev, Victor, Bruggeman, Sophia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Medulloblastoma
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477304/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.167
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