MEDU-07. THE DEVELOPMENTAL STAGE OF THE MEDULLOBLASTOMA CELL-OF-ORIGIN IS MAINTAINED IN CANCER AND RESTRICTS HEDGEHOG PATHWAY USAGE AND DRUG SENSITIVITY

Sonic Hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) population that depends on Hedgehog signaling for its expansion. While SHH tumors are characterized by an overall deregulation of this pathway, they also exhibit aberrations that are specific for pat...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Smit, Marlinde, Armandari, Inna, Bockaj, Irena, Martini, Tosca, Zomerman, Walderik, Siragna, Zillah, Meeuwsen-de Boer, Tiny, Scherpen, Frank, Schoots, Mirthe, Ritsema, Martha, den Dunnen, Wilfred, Hoving, Eelco, Paridaen, Judith, de Haan, Gerald, Guryev, Victor, Bruggeman, Sophia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Medulloblastoma
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477304/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.167
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