Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma

Up to now, several clinical studies have been started investigating the relevance of receptor tyrosine kinase (RTK) inhibitors upon progression free survival in various pediatric brain tumors. However, single targeted kinase inhibition failed, possibly due to tumor resistance mechanisms. The present...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS One
Κύριοι συγγραφείς: Sie, Mariska, den Dunnen, Wilfred F. A., Lourens, Harm Jan, Meeuwsen-de Boer, Tiny G. J., Scherpen, Frank J. G., Zomerman, Walderik W., Kampen, Kim R., Hoving, Eelco W., de Bont, Eveline S. J. M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2015
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370756/
https://ncbi.nlm.nih.gov/pubmed/25799134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122555
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