Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma

Up to now, several clinical studies have been started investigating the relevance of receptor tyrosine kinase (RTK) inhibitors upon progression free survival in various pediatric brain tumors. However, single targeted kinase inhibition failed, possibly due to tumor resistance mechanisms. The present...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Sie, Mariska, den Dunnen, Wilfred F. A., Lourens, Harm Jan, Meeuwsen-de Boer, Tiny G. J., Scherpen, Frank J. G., Zomerman, Walderik W., Kampen, Kim R., Hoving, Eelco W., de Bont, Eveline S. J. M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370756/
https://ncbi.nlm.nih.gov/pubmed/25799134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122555
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