Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma

Up to now, several clinical studies have been started investigating the relevance of receptor tyrosine kinase (RTK) inhibitors upon progression free survival in various pediatric brain tumors. However, single targeted kinase inhibition failed, possibly due to tumor resistance mechanisms. The present...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sie, Mariska, den Dunnen, Wilfred F. A., Lourens, Harm Jan, Meeuwsen-de Boer, Tiny G. J., Scherpen, Frank J. G., Zomerman, Walderik W., Kampen, Kim R., Hoving, Eelco W., de Bont, Eveline S. J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370756/
https://ncbi.nlm.nih.gov/pubmed/25799134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122555
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