DIPG-11. ACTIVATION OF RAS SIGNALING AND DISTINCT MITOGEN-ACTIVATED PROTEIN KINASES (MAPKs) PROVIDES UNIQUE THERAPEUTIC VULNERABILITIES IN MUTANT HISTONE DIPG

Diffuse intrinsic pontine gliomas (DIPGs) are incurable pediatric brain tumors with an aggressive onset. Apart from irradiation, there are currently no effective therapies available for DIPG patients, who have a median survival time of less than one year. DIPG cells possess a mutation in histone H3...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Koncar, Robert, Stanton, Ann-Catherine, Dey, Brittany, Agrawal, Nishant, Wassell, Michelle, McCarl, Lauren, Locke, Abigail, Sanders, Lauren, Vaske, Olena Morozova, Kohanbash, Gary, Felker, James, James, C David, Hashizume, Rintaro, Broniscer, Alberto, Pollack, Ian, Agnihotri, Sameer
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Diffuse Intrinsic Pontine Glioma (DIPG)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477254/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.032
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