DIPG-08. THE ROLE OF KMT5B/C AND H4K20 DI/TRIMETHYLATION IN DIPG

Diffuse intrinsic pontine glioma (DIPG) are incurable childhood brain tumours marked by alterations in histone 3 in the form of somatic K27M mutations and loss of H3K27 trimethylation (H3K27me3). These highly aggressive tumours display extensive intratumoral heterogeneity, despite their relatively m...

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Опубликовано в: :Neuro Oncol
Главные авторы: Kessler, Ketty, Mackay, Alan, Molinari, Valeria, Burford, Anna, Bjerke, Lynn, Temelso, Sara, Vinci, Mara, Jones, Chris
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Diffuse Intrinsic Pontine Glioma (DIPG)
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477248/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.029
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