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FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates
The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear. Here, we show that disordered residues 326–380 of p62 directly interact...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477179/ https://ncbi.nlm.nih.gov/pubmed/30853400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.035 |
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