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FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates
The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear. Here, we show that disordered residues 326–380 of p62 directly interact...
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| 出版年: | Mol Cell |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cell Press
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477179/ https://ncbi.nlm.nih.gov/pubmed/30853400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.035 |
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