FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates

The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear. Here, we show that disordered residues 326–380 of p62 directly interact...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Turco, Eleonora, Witt, Marie, Abert, Christine, Bock-Bierbaum, Tobias, Su, Ming-Yuan, Trapannone, Riccardo, Sztacho, Martin, Danieli, Alberto, Shi, Xiaoshan, Zaffagnini, Gabriele, Gamper, Annamaria, Schuschnig, Martina, Fracchiolla, Dorotea, Bernklau, Daniel, Romanov, Julia, Hartl, Markus, Hurley, James H., Daumke, Oliver, Martens, Sascha
Format: Artigo
Language:Inglês
Published: Cell Press 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477179/
https://ncbi.nlm.nih.gov/pubmed/30853400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.035
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