Phasing out the bad—How SQSTM1/p62 sequesters ubiquitinated proteins for degradation by autophagy

The degradation of misfolded, ubiquitinated proteins is essential for cellular homeostasis. These proteins are primarily degraded by the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy serves as a backup mechanism when the UPS is overloaded. How autophagy and the UPS are coordinated i...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Zaffagnini, Gabriele, Savova, Adriana, Danieli, Alberto, Romanov, Julia, Tremel, Shirley, Ebner, Michael, Peterbauer, Thomas, Sztacho, Martin, Trapannone, Riccardo, Tarafder, Abul K., Sachse, Carsten, Martens, Sascha
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Commentary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103668/
https://ncbi.nlm.nih.gov/pubmed/29929426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1462079
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